DR
Académico · Postgrado UdeC
DAVID MAURICIO RAMIREZ SANCHEZ
Doctor en Ciencias Aplicadas
Universidad de Talca
dramirezs@udec.cl-
Bromhexine inhibits SARS-CoV-2 Omicron and variant pseudovirus infection via ACE2-targeted mechanisms
FRONTIERS IN PHARMACOLOGY 2026 ARTÍCULO WOS - SCOPUS AUTOR
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Molecular Mechanism of Beta-Amyloid Aggregation Inhibition by KLVFF
JOURNAL OF CHEMICAL INFORMATION AND MODELING 2026 ARTÍCULO WOS - SCOPUS AUTOR
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Identification of Potential Multitarget Directed Ligands for Alzheimer's Disease by Coupling Virtual Screening and Experimental Validation
JOURNAL OF CHEMICAL INFORMATION AND MODELING 2026 ARTÍCULO WOS - SCOPUS AUTOR
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Virtual Screening Targeting LasR and Elastase of Pseudomonas aeruginosa Followed by In Vitro Antibacterial Evaluation
SCIENTIA PHARMACEUTICA 2026 ARTÍCULO EMERGENTE - SCOPUS AUTOR
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MicroRNA signature of lymphoblasts from amyotrophic lateral sclerosis patients as potential clinical biomarkers
NEUROBIOLOGY OF DISEASE 2025 ARTÍCULO WOS - SCOPUS AUTOR
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The ROCK Inhibitor Fasudil and Sertraline Share Morphological and Molecular Effects in the Hippocampus of Chronically Stressed Rats: Exploring Common Antidepressant Pathways by Network Pharmacology
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE 2025 ARTÍCULO EMERGENTE - SCOPUS AUTOR
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Identification of druggable binding sites and small molecules as modulators of TMC1
COMMUNICATIONS BIOLOGY 2025 ARTÍCULO WOS - SCOPUS AUTOR
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Novel neuroglobin boosters as a therapeutic strategy for traumatic brain injury
INTERNATIONAL IMMUNOPHARMACOLOGY 2025 ARTÍCULO WOS - SCOPUS AUTOR
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Discovery of a brain penetrant SGK1 inhibitor using a ligand- and structure-based virtual screening methodology
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2025 ARTÍCULO WOS - SCOPUS AUTOR
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Differential Effects of Marimastat and Prinomastat on the Metalloprotease Activity of Various Snake Venoms
TOXINS 2025 ARTÍCULO WOS - SCOPUS AUTOR
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Antibacterial and Antiviral Properties of Chenopodin-Derived Synthetic Peptides
ANTIBIOTICS-BASEL 2024 ARTÍCULO WOS - SCOPUS AUTOR
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Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2024 ARTÍCULO WOS - SCOPUS AUTOR
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Enzymatic Metabolic Switches of Astrocyte Response to Lipotoxicity as Potential Therapeutic Targets for Nervous System Diseases
PHARMACEUTICALS 2024 ARTÍCULO WOS - SCOPUS AUTOR
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Repurposing the Open Global Health Library for the discovery of novel Mpro destabilizers with scope as broad-spectrum antivirals
FRONTIERS IN PHARMACOLOGY 2024 ARTÍCULO WOS - SCOPUS AUTOR
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Editorial: Pharmacoinformatics: new developments and challenges in drug design
FRONTIERS IN PHARMACOLOGY 2024 OTRO TIPO EN REVISTA WOS - SCOPUS AUTOR
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Identification of Antioxidant Methyl Derivatives of Ortho-Carbonyl Hydroquinones That Reduce Caco-2 Cell Energetic Metabolism and Alpha-Glucosidase Activity
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024 ARTÍCULO WOS - SCOPUS AUTOR
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Design of ß-Keto Esters with Antibacterial Activity: Synthesis, In Vitro Evaluation, and Theoretical Assessment of Their Reactivity and Quorum-Sensing Inhibition Capacity
SIN REVISTA 2024 CAPÍTULO DE LIBRO AUTOR -
Constitutive sodium permeability in a C. elegans two-pore domain potassium channel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2024 ARTÍCULO WOS - SCOPUS AUTOR
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Pharmacoinformatics: New developments and challenges in drug design
SIN REVISTA 2024 LIBRO AUTOR -
AlzyFinder: A Machine-Learning-Driven Platform for Ligand-Based Virtual Screening and Network Pharmacology
JOURNAL OF CHEMICAL INFORMATION AND MODELING 2024 ARTÍCULO WOS - SCOPUS AUTOR
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Intragastric administration of short chain fatty acids greatly reduces voluntary ethanol intake in rats
SCIENTIFIC REPORTS 2024 ARTÍCULO WOS - SCOPUS AUTOR
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Impedimetric Sensor for SARS-CoV-2 Spike Protein Detection: Performance Assessment with an ACE2 Peptide-Mimic/Graphite Interface
BIOSENSORS 2024 ARTÍCULO WOS - SCOPUS AUTOR
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Phase IIa randomized placebocontrolled clinical trial to evaluate the efficacy of bromhexine in combination with standard therapy in the early treatment of COVID-19 in primary care patients
REVISTA MEDICA DE CHILE 2024 ARTÍCULO WOS - SCIELO - SCOPUS AUTOR
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Anti-Inflammatory Effect of Izalpinin Derived from Chromolaena leivensis: ¿-Carrageenan-Induced Paw Edema and In Silico Model
MOLECULES 2023 ARTÍCULO WOS - SCOPUS AUTOR
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Iridoid esters from Valeriana pavonii Poepp. & Endl. as GABAA modulators: Structural insights in their binding mode and structure-activity relationship
JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH 2023 ARTÍCULO EMERGENTE - DIRECTORIO - SCOPUS AUTOR
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Trends and challenges in chemoinformatics research in Latin America
ARTIFICIAL INTELLIGENCE IN THE LIFE SCIENCES 2023 ARTÍCULO AUTOR
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Network pharmacology and topological analysis on tibolone metabolites and their molecular mechanisms in traumatic brain injury
BIOMEDICINE & PHARMACOTHERAPY 2023 ARTÍCULO WOS - SCOPUS AUTOR
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Design of ß-Keto Esters with Antibacterial Activity: Synthesis, In Vitro Evaluation, and Theoretical Assessment of Their Reactivity and Quorum-Sensing Inhibition Capacity
PHARMACEUTICALS 2023 ARTÍCULO WOS - SCOPUS AUTOR
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Crystal structure, Hirshfeld surface analysis, and molecular dynamics simulations of two isostructural N-propargyl-4-(2-oxopyrrolidin-1-yl)-1,2,3,4-tetrahydroquinolines
JOURNAL OF MOLECULAR STRUCTURE 2022 ARTÍCULO WOS - SCOPUS AUTOR
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TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy
JOURNAL OF MEDICINAL CHEMISTRY 2022 ARTÍCULO WOS - SCOPUS AUTOR
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Structural Insights into the Substrate Transport Mechanisms in GTR Transporters through Ensemble Docking
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022 ARTÍCULO WOS - SCOPUS AUTOR
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Identification of HMGCR, PPGARG and prohibitin as potential druggable targets of dihydrotestosterone for treatment against traumatic brain injury using system pharmacology
INTERNATIONAL IMMUNOPHARMACOLOGY 2022 ARTÍCULO WOS - SCOPUS AUTOR
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Tibolone Pre-Treatment Ameliorates the Dysregulation of Protein Translation and Transport Generated by Palmitic Acid-Induced Lipotoxicity in Human Astrocytes: A Label-Free MS-Based Proteomics and Network Analysis
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022 ARTÍCULO WOS - SCOPUS AUTOR
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Common Structural Pattern for Flecainide Binding in Atrial-Selective Kv1.5 and Nav1.5 Channels: A Computational Approach
PHARMACEUTICS 2022 ARTÍCULO WOS - SCOPUS AUTOR
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Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19
FRONTIERS IN PHARMACOLOGY 2022 ARTÍCULO WOS - SCOPUS AUTOR
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New Drug Design Avenues Targeting Alzheimer's Disease by Pharmacoinformatics-Aided Tools
PHARMACEUTICS 2022 REVIEW WOS - SCOPUS AUTOR
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Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability
JOURNAL OF MEDICINAL CHEMISTRY 2022 ARTÍCULO WOS - SCOPUS AUTOR
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Drug repositioning as an alternative for the treatment of COVID-19 and future pandemics
ACTUALIDAD EN FARMACOLOGIA Y TERAPEUTICA 2022 OTRO TIPO EN REVISTA AUTOR -
Targeting nuclear protein TDP-43 by cell division cycle kinase 7 inhibitors: A new therapeutic approach for amyotrophic lateral
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021 ARTÍCULO WOS - SCOPUS AUTOR
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PSC-db: A Structured and Searchable 3D-Database for Plant Secondary Compounds
MOLECULES 2021 ARTÍCULO WOS - SCOPUS AUTOR
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Host-Directed FDA-Approved Drugs with Antiviral Activity against SARS-CoV-2 Identified by Hierarchical In Silico/In Vitro Screening Methods
PHARMACEUTICALS 2021 ARTÍCULO WOS - SCOPUS AUTOR
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Screening for Interacting Proteins with Peptide Biomarker of Blood-Brain Barrier Alteration under Inflammatory Conditions
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2021 ARTÍCULO WOS - SCOPUS AUTOR
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Identification of a critical binding site for local anaesthetics in the side pockets of K(v)1 channels
BRITISH JOURNAL OF PHARMACOLOGY 2021 ARTÍCULO WOS - SCOPUS AUTOR
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5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis
MOLECULES 2021 ARTÍCULO WOS - SCOPUS AUTOR
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From Kinase Inhibitors to Multitarget Ligands as Powerful Drug Leads for Alzheimer's Disease using Protein-Templated Synthesis
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2021 ARTÍCULO WOS - SCOPUS AUTOR
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Application of ensemble pharmacophore-based virtual screening to the discovery of novel antimitotic tubulin inhibitors
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 2021 ARTÍCULO WOS - SCOPUS AUTOR
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Antimicrobial properties of novel ionic liquids derived from imidazolium cation with phenolic functional groups
BIOORGANIC CHEMISTRY 2021 ARTÍCULO WOS - SCOPUS AUTOR
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Identification of Mycobacterium tuberculosis CtpF as a target for designing new antituberculous compounds
BIOORGANIC & MEDICINAL CHEMISTRY 2020 ARTÍCULO WOS - SCOPUS AUTOR
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Elucidating the Structural Basis of the Intracellular pH Sensing Mechanism of TASK-2 K2P Channels
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020 ARTÍCULO WOS - SCOPUS AUTOR
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Structural and functional computational analysis of nicotine analogs as potential neuroprotective compounds in Parkinson disease
COMPUTATIONAL BIOLOGY AND CHEMISTRY 2020 ARTÍCULO SCOPUS AUTOR
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COVID-19: Drug Targets and Potential Treatments
JOURNAL OF MEDICINAL CHEMISTRY 2020 ARTÍCULO WOS - SCOPUS AUTOR
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Analysis of theZonula occludensToxin Found in the Genome of the Chilean Non-toxigenicVibrio parahaemolyticusStrain PMC53.7
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY 2020 ARTÍCULO WOS - SCOPUS AUTOR
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The molecular basis for an allosteric inhibition of K+-flux gating in K-2P channels
ELIFE 2019 ARTÍCULO WOS - SCOPUS AUTOR
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The interplay of the metallosensor CueR with two distinct CopZ chaperones defines copper homeostasis in Pseudomonas aeruginosa
JOURNAL OF BIOLOGICAL CHEMISTRY 2019 ARTÍCULO WOS - SCOPUS AUTOR
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Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019 ARTÍCULO WOS - SCOPUS AUTOR
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Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2019 ARTÍCULO WOS - SCOPUS AUTOR
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TASK Channels Pharmacology: New Challenges in Drug Design
JOURNAL OF MEDICINAL CHEMISTRY 2019 ARTÍCULO WOS - SCOPUS AUTOR
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Theoretical and Experimental Approaches Aimed at Drug Design Targeting Neurodegenerative Diseases
PROCESSES 2019 REVIEW WOS - SCOPUS AUTOR
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Computational Studies of Snake Venom Toxins
TOXINS 2018 REVIEW WOS - SCOPUS AUTOR
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An important role for periplasmic storage in Pseudomonas aeruginosa copper homeostasis revealed by a combined experimental and computational modeling study
MOLECULAR MICROBIOLOGY 2018 ARTÍCULO WOS - SCOPUS AUTOR
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Novel Alkylimidazolium Ionic Liquids as an Antibacterial Alternative to Pathogens of the Skin and Soft Tissue Infections
MOLECULES 2018 ARTÍCULO WOS - SCOPUS AUTOR
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Is It Reliable to Take the Molecular Docking Top Scoring Position as the Best Solution without Considering Available Structural Data?
MOLECULES 2018 ARTÍCULO WOS - SCOPUS AUTOR
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HCN Channels: New Therapeutic Targets for Pain Treatment
MOLECULES 2018 REVIEW WOS - SCOPUS AUTOR
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Side Fenestrations Provide an "Anchor" for a Stable Binding of A1899 to the Pore of TASK-1 Potassium Channels
MOLECULAR PHARMACEUTICS 2017 ARTÍCULO WOS - SCOPUS AUTOR
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Origin and evolution of transporter substrate specificity within the NPF family
ELIFE 2017 ARTÍCULO WOS - SCOPUS AUTOR
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Conotoxins as Tools to Understand the Physiological Function of Voltage-Gated Calcium (Ca-V) Channels
MARINE DRUGS 2017 REVIEW WOS - SCOPUS AUTOR
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Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A(2), ApITx-I, purified from Agkistrodon piscivorus leucostoma snake venom
TOXICON 2017 ARTÍCULO WOS - SCOPUS AUTOR
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Computational methods applied to rational drug design
OPEN MEDICINAL CHEMISTRY JOURNAL 2016 ARTÍCULO SCOPUS AUTOR
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Is It Reliable to Use Common Molecular Docking Methods for Comparing the Binding Affinities of Enantiomer Pairs for Their Protein Target?
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2016 ARTÍCULO WOS - SCOPUS AUTOR
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Functional mutagenesis screens reveal the 'cap structure' formation in disulfide-bridge free TASK channels
SCIENTIFIC REPORTS 2016 ARTÍCULO WOS - SCOPUS AUTOR
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CoaTx-II, a new dimeric Lys49 phospholipase A(2) from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological roles
TOXICON 2016 ARTÍCULO WOS - SCOPUS AUTOR
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Novel N-allyl/propargyl tetrahydroquinolines: Synthesis via Three-component Cationic Imino Diels-Alder Reaction, Binding Prediction, and Evaluation as Cholinesterase Inhibitors
CHEMICAL BIOLOGY & DRUG DESIGN 2016 ARTÍCULO WOS - SCOPUS AUTOR
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K-2P channels in plants and animals
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2015 REVIEW WOS - SCOPUS AUTOR
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Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 2015 ARTÍCULO WOS - SCOPUS AUTOR
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Theoretical and Experimental Exploration of Organic Synthesis Routes to Obtain Natural Rubber Analogues
JOURNAL OF MATERIALS SCIENCE AND ENGINEERING A 2014 ARTÍCULO AUTOR
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Computational insights of the interaction among sea anemones neurotoxins and Kv1.3 channel
BIOINFORMATICS AND BIOLOGY INSIGHTS 2014 ARTÍCULO EMERGENTE - SCOPUS AUTOR